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Related Concept Videos

Membrane Lipids01:32

Membrane Lipids

34.6K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

Histone Modification

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No description available
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Histone Variants at the Centromere02:30

Histone Variants at the Centromere

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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What are Lipids?01:38

What are Lipids?

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Overview
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Structure of Lipids03:38

Structure of Lipids

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Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
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Related Experiment Video

Updated: Feb 16, 2026

Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes
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Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes

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Membrane Lipids Speak to Histones.

Yuxiang Zheng1, Lewis C Cantley1

  • 1Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.

Molecular Cell
|April 22, 2017
PubMed
Summary

Methionine metabolism impacts cellular signaling and gene expression in yeast. This study reveals how these metabolic pathways influence key cellular processes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Yeast Genetics

Background:

  • Methionine metabolism is a critical cellular pathway.
  • Its role in regulating signal transduction and gene expression is not fully understood.
  • Budding yeast (Saccharomyces cerevisiae) serves as a model organism.

Purpose of the Study:

  • To investigate the influence of methionine metabolism on signal transduction pathways.
  • To explore how methionine metabolism affects gene expression profiles in budding yeast.
  • To elucidate the connection between metabolic state and cellular regulatory networks.

Main Methods:

  • Utilized a combination of genetic manipulation techniques.
  • Employed metabolomic profiling to analyze metabolite levels.
Keywords:
epigeneticshistonelipidmetabolism

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  • Conducted transcriptomic analysis to assess gene expression changes.

    • Main Results:

    • Identified specific metabolic alterations in methionine pathways.
    • Observed significant changes in signal transduction components.
    • Documented differential gene expression patterns correlated with metabolic status.

    Conclusions:

    • Methionine metabolism plays a regulatory role in yeast signal transduction.
    • Metabolic flux through methionine pathways directly impacts gene expression.
    • Findings provide insights into metabolic control of cellular processes.