Related Experiment Video
Updated: Mar 3, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Cutaneous Malignant Melanoma With Rhabdoid Morphology and Smooth Muscle Differentiation: A Challenging
Lucía Prieto-Torres1, Victoria Alegría-Landa, Concepción Llanos
1*Department of Dermatology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain;†Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain;‡Department of Pathology, Complejo Hospitalario de Navarra, Pamplona, Spain; and§Dermathopathologie Friedrichshafen, Friedrichshafen, Germany.
Abstract:
Divergent differentiation or metaplastic change is a rare feature exhibited occasionally in malignant melanoma (MM), which is characterized by the development of morphologically, immunochemically, and/or ultrastructurally nonmelanocytic cells within the tumor. Smooth muscle differentiation in MM is an exceedingly rare phenomenon reported only in a few cases in the literature. We report the case of a 69-year-old woman who presented with a pure dermal amelanotic MM with smooth muscle cell differentiation and an area of rhabdoid morphology, which made the accurate histopathologic diagnostic of MM challenging.
