Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis

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Ming-Yue Wu1,2, Yang Wu3, Yong Zhang4

  • 1Stomatologic Hospital & College, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, 230032, China.

BMC Ophthalmology
|April 23, 2017
PubMed
Abstract

Insights

Matrix metalloproteinase-9 (MMP-9) gene polymorphisms, specifically rs17576 G>A and rs3918249 C>T, are associated with a reduced risk of glaucoma. The MMP-9 rs17576 G>A polymorphism may offer protection against glaucoma in Caucasian populations.

Area of Science:

  • Genetics
  • Ophthalmology
  • Molecular Biology

Background:

  • Matrix metalloproteinases (MMPs) are implicated in glaucoma pathogenesis.
  • Previous studies on MMPs polymorphisms and glaucoma risk have yielded controversial results.
  • A comprehensive meta-analysis is needed to clarify these associations.

Purpose of the Study:

  • To evaluate the precise associations between matrix metalloproteinases (MMPs) gene polymorphisms and the risk of developing glaucoma.
  • To clarify the conflicting findings in previous research regarding MMPs and glaucoma.
  • To identify specific MMPs polymorphisms that may influence glaucoma susceptibility.

Main Methods:

  • A systematic review and meta-analysis of relevant studies were conducted using four electronic databases.
  • Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between common MMPs polymorphisms and glaucoma risk.
  • Statistical analyses included heterogeneity, publication bias, and sensitivity analyses to ensure robustness.

Main Results:

  • The meta-analysis included 11 studies with 2,388 cases and 2,319 controls.
  • Significant associations were found between MMP-9 rs17576 G>A and MMP-9 rs3918249 C>T polymorphisms and glaucoma risk.
  • Subgroup analysis indicated that MMP-9 rs17576 G>A polymorphism is associated with reduced glaucoma risk in the Caucasian population.

Conclusions:

  • The MMP-9 rs17576 G>A polymorphism may act as a protective factor against glaucoma development.
  • The findings suggest a potential genetic link between MMP-9 variations and glaucoma susceptibility, particularly in Caucasians.
  • Further research may elucidate the precise mechanisms underlying this protective effect.
Keywords:
GlaucomaMatrix metalloproteinasesPolymorphism

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