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Related Experiment Videos

Evoked potentials in chronic inflammatory demyelinating polyneuropathy.

A Pakalnis1, M E Drake, R J Barohn

  • 1Department of Neurology, Ohio State University Hospitals, Columbus.

Archives of Neurology
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

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Chronic inflammatory demyelinating polyneuropathy (CIDP) may involve central nervous system demyelination, detectable by evoked potentials. This suggests a shared cause for central and peripheral nerve damage in CIDP patients.

Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Electrophysiology

Background:

  • Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare autoimmune disorder affecting peripheral nerves.
  • The extent of central nervous system (CNS) involvement in CIDP is not fully understood.
  • Evoked potentials are electrophysiological tests that measure nerve signal conduction.

Purpose of the Study:

  • To investigate the presence of central nervous system demyelination in patients with CIDP using evoked potentials.
  • To compare the diagnostic utility of evoked potentials with magnetic resonance imaging (MRI) in detecting CNS demyelination in CIDP.

Main Methods:

  • Studied 18 patients diagnosed with CIDP.
  • Performed visual evoked responses (VERs) and brain-stem auditory evoked responses (BAERs).

Related Experiment Videos

  • Correlated evoked potential findings with magnetic resonance imaging (MRI) results.

    • Main Results:

    • Evoked potentials were abnormal in 9 out of 18 (50%) CIDP patients.
    • MRI confirmed CNS demyelination in 5 of these 9 patients.
    • Evoked potentials detected probable anterior optic pathway involvement in 4 patients not evident on MRI.

    Conclusions:

    • Evoked potentials can identify central nervous system demyelination in CIDP patients.
    • Findings support an association between CIDP and central demyelinating disorders.
    • Suggests a potential common pathogenic mechanism for central and peripheral demyelination in CIDP.