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Updated: Mar 3, 2026
Infant Auditory Processing and Event-related Brain Oscillations
Published on: July 1, 2015
Short-term outcome of functional integrity of the auditory brainstem in term infants who suffer perinatal asphyxia
1Division of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
Objectives:
To assess short-term outcome of impaired functional integrity of the auditory brainstem in term infants who suffer perinatal asphyxia.
Methods:
Maximum length sequence brainstem auditory evoked response (MLS BAER) was recorded and analyzed at a mean age of 3months in term infants after perinatal asphyxia. The data were compared with age-matched normal term infants.
Results:
The infants after asphyxia showed an increase in the latency of MLS BAER wave III at 91, 455 and 910/s, and wave V at all click rates of 91-910/s. The interpeak intervals in the infants after asphyxia were increased at almost all click rates. The IV and I-III intervals were increased at all click rates, and the III-V interval was increased at 455 and 910/s. These increases were generally more significant at higher than at lower click rates. The amplitudes of waves I, III and V in the infants after asphyxia were reduced at all click rates. The V/I amplitude ratio was increased at 91-455/s clicks. The slope of III-V interval-rate function was abnormally increased. 17.1% of the infants after asphyxia had an abnormal increase in IV intervals.
Conclusions:
MLS BAER was moderately abnormal at 3months of age in term infants after perinatal asphyxia, suggesting moderate impairment in the functional integrity of the auditory brainstem. The impairment occurs in 17.1% of the infants. Compared with that found at term, the impairment has improved, but not completely recovered.
