Related Experiment Video
Updated: Mar 3, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
[Behavioral activation programs: A tool for treating depression efficiently]
C Dondé1, R Moirand1, A Carre2
1Université Claude-Bernard Lyon 1, 43, boulevard du 11-Novembre-1918, 69100 Villeurbanne, France; Institut national de la santé et de la recherche médicale (Inserm) U1028, centre national de la recherche en santé (CNRS) UMR5292, équipe PSYR2, centre de recherche en neurosciences de Lyon (CRNL), 69675 Bron, France; Centre hospitalier Le Vinatier, bâtiment 416, 95, boulevard Pinel, BP 30039, 69675 Bron, France.
Introduction:
Major depressive disorder (MDD) is a debilitating disorder, and its treatment often requires complex and costly psychological therapies. Behavioral activation (BA) is a simple, effective and affordable psychotherapy recommended in the treatment of MDD.
Objectives:
(i) Explain the theoretical basis of BA and its application in clinical practice. (ii) Review the randomized controlled trials examining BA as a treatment for MDD through a systematic search of the existing literature.
Methods:
Medline and ClinicalTrials databases were searched with the following keywords: ("behavioral activation" OR "behavioural activation") AND ("therapy" OR "psychotherapy"). (i) Articles describing BA's theoretical foundations and principles of therapy were selected. (ii) Randomized controlled trials studying BA as a treatment for depression were selected according to the PRISMA criteria.
Results:
(i) BA is a behavioral therapy that helps patients to increase their behaviors towards rewarding and/or pleasant activities, and to decrease avoidant behaviors maintaining negative affects by negative reinforcement. BA also tends to increase behaviors towards life-goals used as positive reinforcement contingencies. BA is a brief and cost effective therapy, which can be evaluated by specific psychometric scales. (ii) BA has a strong therapeutic effect in MDD as evaluated by several randomized controlled trials of good quality.
Conclusion:
BA is a simple, affordable and effective treatment for MDD. Data is insufficient to provide proof for the interest of using commitment to life-goals as reinforcement contingencies. Behavioral inhibition is encountered amongst several psychiatric disorders and more studies should be conducted to discuss its use for other diseases such as schizophrenia or anxiety disorders.
Related Concept Videos
Behavior Modification
A real-world application of operant conditioning principles is applied...
Behavior Therapy
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Rational Emotive Behavior Therapy
Cognitive Therapy
Antidepressant Drugs: MAOIs and Other Agents
Modeling in Therapy
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...

