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Updated: Mar 3, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Tissue adaptation: Implications for gut immunity and tolerance
Ana M C Faria1,2, Bernardo S Reis1, Daniel Mucida1
1Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065 anacaetanofaria@gmail.com breis@rockefeller.edu mucida@rockefeller.edu.
Abstract:
Tissue adaptation is an intrinsic component of immune cell development, influencing both resistance to pathogens and tolerance. Chronically stimulated surfaces of the body, in particular the gut mucosa, are the major sites where immune cells traffic and reside. Their adaptation to these environments requires constant discrimination between natural stimulation coming from harmless microbiota and food, and pathogens that need to be cleared. This review will focus on the adaptation of lymphocytes to the gut mucosa, a highly specialized environment that can help us understand the plasticity of leukocytes arriving at various tissue sites and how tissue-related factors operate to shape immune cell fate and function.
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