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A Bacterial Cause of Cancer: An Historical Essay
1Division of Hematology and Oncology, Department of Medicine and the James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA mal@urmc.rochester.edu.
Abstract:
This article reviews the history of the discovery of microbes that increase the risk of cancer of some tissues with a special emphasis on the bacterium Helicobacter pylori and the role played by two Australian physicians, neither schooled in research, who had open minds about the shibboleth that mycobacteria (acid-fast organisms) can survive the acid environment of the stomach, but that other pathogenic bacteria cannot. They discovered one of the most important human pathogens, Helicobacter pylori, and showed it capable of inducing severe gastric inflammatory disease. Subsequently, others built on their observations and showed it capable of inducing two gastric neoplasms: carcinoma and lymphoma. 2017;22:542-548.
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