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Updated: Mar 3, 2026
Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
Prognostic impact of PD-1 and its ligands in renal cell carcinoma
Franziska Erlmeier1,2, Wilko Weichert3,4, Andres Jan Schrader5,6
1Institute for Pathology and Pathological Anatomy, Technische Universität München, Trogerstraße 18, 81675, Munich, Germany. f.erlmeier@tum.de.
Abstract:
Programmed death-1 receptor (PD-1) and programmed death-1 receptor-ligand (PD-L1) have been suggested to play a role as prognostic markers in clear cell renal cell carcinoma (ccRCC). The association between PD-L1 and prognosis seems to be more robust than for PD-1. Further, preliminary analyses suggest that neither PD-1 nor its ligands play a role as prognostic markers in non-clear cell RCC, while the prognostic role of PD-L2 in ccRCC as well as in non-clear cell RCC remains unclear.
