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Cognitive and psychiatric symptoms in Wilson disease
Paula Zimbrean1, Joanna Seniów2
1Departments of Psychiatry and Surgery (Transplant), Yale University, New Haven, CT, USA.
Abstract:
Wilson disease - can present with such a variety of psychiatric and cognitive symptoms that it has been named the "great masquerader." Symptoms may include cognitive deficits, impairment of executive function, mood disturbance or psychosis. These impairments may occur in different stages of the disease and with varying intensity in individual patients. This chapter reviews the literature and authors' clinical experiences of the assessment, mechanism, and prevalence of cognitive and psychiatric pathology occurring in Wilson disease. Evidence of pharmacologic and nonpharmacologic treatments is also discussed.
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