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A BrdU-enhanceable fragile site or viral modification site at 11q23.1 in lymphoblastoid cultures
G R Sutherland1, E Baker, D F Callen
1Cytogenetics Unit, Adelaide Children's Hospital, Australia.
Cytogenetics and Cell Genetics
|January 1, 1988
Abstract:
Chromosomes prepared from EBV-transformed lymphoblastoid cell lines show an achromatic gap or fragile site-like lesion at 11q23.1. The low spontaneous expression of this lesion is greatly enhanced by BrdU and n-butyric acid. The lesion was expressed homozygously in all 16 cell lines examined. It is suggested that the lesion is a viral chromosome modification site.