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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Paraneoplastic jaundice and prostate cancer
Ana Claudia Vieira1, Maria Joana Alvarenga2, Jose Carlos Santos3
1Pneumologia, Hospital de Egas Moniz, Lisboa, Portugal.
BMJ Case Reports
|April 24, 2017
Summary
This case study highlights an unusual presentation of prostate cancer causing jaundice via paraneoplastic syndrome. Early treatment led to symptom resolution in this elderly male patient.
Area of Science:
- Oncology
- Hepatology
- Immunology
Background:
- Cholestasis is a multifactorial condition with diverse etiologies.
- Prostate cancer is a common diagnosis in elderly men.
- Paraneoplastic syndromes can manifest with varied clinical presentations.
Observation:
- A 78-year-old male presented with jaundice, an uncommon manifestation of prostate cancer.
- This presentation is associated with a rare paraneoplastic syndrome, with only 11 reported cases.
- Prostate cancer-associated jaundice in this context is infrequently documented.
Findings:
- Interleukin-6 and other pro-inflammatory cytokines are implicated in the syndrome's pathophysiology.
- The patient's jaundice was attributed to a paraneoplastic process linked to prostate cancer.
- The specific mechanisms linking prostate cancer to cholestatic jaundice remain under investigation.
Implications:
- This case expands the known spectrum of prostate cancer's paraneoplastic manifestations.
- Understanding the role of cytokines may offer novel therapeutic targets for similar conditions.
- Prompt diagnosis and treatment of paraneoplastic jaundice can lead to favorable patient outcomes.
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