Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

1.2K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.2K
Vaccinations01:51

Vaccinations

52.8K
Overview
52.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Who measures the measurers: Closing the administrative accountability gap in non-profit acute care hospitals.

BMC health services research·2026
Same author

Human neural organoid modeling of diffuse midline glioma captures the complexity of patient tumors.

Journal of neuro-oncology·2026
Same author

Radiopharmaceutical therapy provides superior survival advantage for leptomeningeal metastasis compared to external beam radiotherapy.

Neuro-oncology·2026
Same author

Glioblastoma immunotherapy in the context of the aging immune system: a systematic review and meta-analysis.

Journal of neuro-oncology·2026
Same author

CASSIA: a multi-agent large language model for automated and interpretable cell annotation.

Nature communications·2025
Same author

Epigenetic regulation of immune cells in central nervous system: from steady state to pathology.

Neurochemistry international·2025

Related Experiment Video

Updated: Mar 3, 2026

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

12.3K

Dendritic cell based vaccination strategy: an evolving paradigm.

Anna C Filley1, Mahua Dey2,3

  • 1Department of Neurosurgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Journal of Neuro-Oncology
|April 24, 2017
PubMed
Summary
This summary is machine-generated.

Malignant gliomas (MG) treatments are limited. Immunotherapy using dendritic cells (DCs) shows promise for stimulating anti-tumor immune responses and improving survival in cancer patients.

Keywords:
Dendritic cell based vaccineGlioblastomaImmunotherapyMalignant glioma

More Related Videos

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
10:35

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

4.1K
Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.8K

Related Experiment Videos

Last Updated: Mar 3, 2026

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
12:43

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

Published on: January 6, 2014

12.3K
Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
10:35

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

4.1K
Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.8K

Area of Science:

  • Neuro-oncology
  • Immunology
  • Cancer Therapy

Background:

  • Malignant gliomas (MG) are primary brain tumors with limited treatment options and high recurrence rates.
  • Current therapies offer modest improvements in survival, highlighting the need for novel treatment strategies.
  • Immunotherapy, particularly dendritic cell (DC)-based vaccines, is a promising approach to stimulate anti-tumor immunity.

Purpose of the Study:

  • To review the role of dendritic cells (DCs) in the tumor microenvironment of malignant gliomas.
  • To summarize the current applications and clinical use of DC-based immunotherapy for cancer.
  • To identify challenges and future directions for developing effective anti-tumor DC vaccines.

Main Methods:

  • Literature review of current research on dendritic cells and malignant gliomas.
  • Analysis of clinical trial data for DC-based vaccinations in various cancers.
  • Synthesis of information on DC function, tumor microenvironment interactions, and therapeutic strategies.

Main Results:

  • Dendritic cells (DCs) are key initiators of adaptive immune responses crucial for immunotherapy.
  • DC-based vaccinations have shown potential in inducing anti-tumor immunity and prolonging survival in cancer patients.
  • The tumor microenvironment presents challenges to DC efficacy in anti-cancer therapy.

Conclusions:

  • Dendritic cell (DC) immunotherapy holds significant potential for treating malignant gliomas.
  • Overcoming challenges within the tumor microenvironment is critical for successful DC-based vaccine development.
  • Further research into novel DC-based vaccine strategies is warranted for improved anti-cancer therapy.