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Related Experiment Video

Updated: Mar 3, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Persistent and recurrent hyperparathyroidism.

Carole Guerin^1,2, Nunzia Cinzia Paladino³, Aoife Lowery⁴

¹Department of Endocrine Surgery, La Conception Hospital, Assistance Publique Hopitaux de Marseille, 147 BD Baille, 13005, Marseille, France. carole.guerin@ap-hm.fr.

Updates in Surgery

|April 24, 2017

Summary

Persistent or recurrent primary hyperparathyroidism (PHPT) requires careful management. Expert centers achieve high cure rates (93-97%) for persistent and recurrent PHPT through specialized reoperation strategies.

Keywords:

Persistent Primary hyperparathyroidism Recurrent Surgery

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Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Area of Science:

Endocrinology
Surgical Oncology
Medical Imaging

Background:

Persistent or recurrent primary hyperparathyroidism (PHPT) affects 2.5-5% of patients despite advances in treatment.
Management strategies for persistent and recurrent PHPT are crucial for patient outcomes.

Purpose of the Study:

To review and outline the management approaches for persistent and recurrent primary hyperparathyroidism.
To provide guidance on reoperation strategies and patient selection for expert centers.

Main Methods:

Literature search of MEDLINE and reference lists for studies on recurrent or persistent hyperparathyroidism within the last 10 years.
Analysis of diagnostic and surgical management options for PHPT recurrence.

Main Results:

Reoperation for PHPT requires confirmation of diagnosis and advanced imaging.
Common causes include single adenoma (68%), multiglandular disease (28%), and parathyroid carcinoma (3%).
High cure rates (93-97%) are achievable in expert centers, balancing risks like hypocalcemia and nerve palsy.

Conclusions:

Management of persistent and recurrent PHPT necessitates confirmation of diagnosis and appropriate imaging.
Reoperation strategies, including focused or bilateral exploration, depend on the underlying pathology.
Patients with PHPT recurrence should be managed in specialized centers with multidisciplinary expertise.