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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Related Experiment Video

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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Immunotherapy in hematologic malignancies: past, present, and future.

Annie Im1, Steven Z Pavletic2

  • 1University of Pittsburgh Cancer Institute, 5150 Centre Ave, Suite 554, Pittsburgh, PA, 15213, USA. imap@upmc.edu.

Journal of Hematology & Oncology
|April 25, 2017
PubMed
Summary

Cancer immunotherapy, a breakthrough in cancer treatment, has evolved significantly. This review explores the history, current applications, and future potential of immunotherapy for hematologic malignancies.

Keywords:
Hematologic malignanciesImmunotherapyStem cell transplantation

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Area of Science:

  • Immunology
  • Oncology
  • Hematology

Background:

  • Cancer immunotherapy has emerged as a leading research area, transforming solid tumor treatments.
  • Immunotherapy was established in treating hematologic malignancies before its 2013 breakthrough designation.

Purpose of the Study:

  • To provide a comprehensive overview of cancer immunotherapy in hematologic malignancies.
  • To examine the historical development, current status, and future prospects of this therapeutic approach.

Main Methods:

  • Literature review
  • Historical analysis
  • Future trend projection

Main Results:

  • Immunotherapy has a long-standing history in treating blood cancers.
  • Recent advancements have broadened its application and efficacy.
  • Future directions indicate continued innovation and expanded use.

Conclusions:

  • Cancer immunotherapy has a significant and evolving role in managing hematologic malignancies.
  • The trajectory suggests ongoing advancements and integration into standard care.
  • Further research is crucial for optimizing outcomes in blood cancers.