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Compulsive Addiction-like Aggressive Behavior in Mice.

Sam A Golden1, Conor Heins1, Marco Venniro1

  • 1Neurobiology of Relapse Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland.

Biological Psychiatry
|April 25, 2017
PubMed
Summary
This summary is machine-generated.

Compulsive aggression in mice shares addiction-like features, including high motivation and relapse vulnerability. A subset of mice displayed addiction-like aggressive behavior, suggesting an evolutionary basis for compulsive aggression.

Keywords:
AddictionAggressionMiceMotivationRelapseReward

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Addiction Research

Background:

  • Human aggression, particularly in incarcerated individuals, shows high motivation and recidivism.
  • These patterns mirror key characteristics of drug addiction, such as compulsive substance seeking and high relapse rates.

Purpose of the Study:

  • To investigate if established rodent models of drug addiction could identify "addiction-like" features in aggressive behavior.
  • To determine if aggression self-administration in mice exhibits characteristics similar to drug addiction.

Main Methods:

  • CD-1 mice were trained to self-administer opportunities to attack other mice using operant conditioning.
  • Relapse vulnerability was assessed after forced abstinence and punishment.
  • Choice-based suppression, progressive ratio responding, and punishment resilience were evaluated in a larger cohort, followed by cluster analysis.

Main Results:

  • Mice demonstrated strong motivation for aggression and vulnerability to relapse during abstinence.
  • Cluster analysis revealed a subpopulation (approx. 19%) exhibiting compulsive, "addiction-like" aggressive behavior.
  • This subset showed reduced alternative reinforcer preference, heightened relapse, increased progressive ratio responding, and resilience to punishment.

Conclusions:

  • Rodent models of drug addiction successfully identified a subpopulation of mice with "addiction-like" aggressive behavior.
  • These findings suggest a potential evolutionary origin for compulsive aggression, linking it to addiction mechanisms.