Related Experiment Video
Updated: Mar 3, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Kleine-Levin syndrome; An update and mini-review
Natan Gadoth1, Arie Oksenberg2
1Department of Neurology, Maynei Hayeshua Medical Center, Bnei Brak, Israel; The Sackler Faculty of Medicine, Tel-Aviv University, Israel; The Sleep Disorders Unit, Loewenstein Hospital - Rehabilitation Center, Raanana, Israel.
Abstract:
Since 1962, when Critchley and Hoffman coined the term Kleine-Levin Syndrome (KLS) for the triad of hypersomnia, excessive eating and "often abnormal behavior" which they have observed in 11 adolescent boys, the number of patients recognized with this rare syndrome expanded, the spectrum of the clinical presentation, disease course, prognosis, gender specificity and the presence of familial cases were established. However, in spite of the progress made in neuroscience, the search for the cause, neuroanatomy, pathophysiology and drug treatment of KLS is still ongoing. In this mini-review we will describe in some detail the scientific efforts made to understand in depth the complex symptomatology of KLS and refer also to updated findings reached up till now.
More Related Videos
03:59Production and Optimization of LTE, a Leishmania tarentolae Derived Cell-Free Protein Expression System for Recombinant Protein Production
Published on: November 8, 2024
11:31Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate
Published on: September 18, 2013
Related Concept Videos
Lysosomal Hydrolases
ATP Synthase: Structure
Smooth Endoplasmic Reticulum
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
Nephrotic Syndrome I : Introduction