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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Cellular Membranes and Drug Transport

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Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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Nanobiotechnology: Cell Membrane-Based Delivery Systems.

Pengfei Zhang1, Gang Liu1,2,3, Xiaoyuan Chen4

  • 1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.

Nano Today
|April 25, 2017
PubMed
Summary
This summary is machine-generated.

Cell membrane-based nanovesicles show great promise for bioinspired drug delivery systems. Their unique combination of natural cell functions and synthetic material flexibility enables advanced nanomedicine and personalized treatments.

Keywords:
Bio-inspired synthesisBiomaterialCell membraneNanobiotechnologyNanovesicles

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • The field of bioinspired drug delivery is rapidly advancing.
  • Cell membrane-based nanovesicles are emerging as a promising technology.

Purpose of the Study:

  • To highlight the potential of cell membrane-based nanovesicles in biomedical applications.
  • To discuss their versatility in designing novel drug formulations.

Main Methods:

  • Review of current research in bioinspired drug delivery.
  • Analysis of the properties of cell membrane-based nanoparticles.

Main Results:

  • Cell membrane-based nanoparticles integrate natural cell membrane functionalities with synthetic nanomaterial properties.
  • This integration offers significant design flexibility for drug delivery systems.

Conclusions:

  • Cell membrane-based nanovesicles represent a versatile platform for advanced nanomedicine.
  • They hold potential for developing personalized drug formulations for future therapeutic applications.