Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

687
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
687
Dissociative Disorders01:27

Dissociative Disorders

706
Dissociative disorders represent complex psychological conditions characterized by disruptions in consciousness, memory, identity, or perception. These disruptions cause individuals to experience a disconnection from their thoughts, emotions, and memories. The phenomenon is not merely an occasional lapse in attention but a profound alteration in mental functioning that can severely impact daily life.
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
706
Dissociative Identity Disorder01:30

Dissociative Identity Disorder

1.3K
Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
1.3K
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

702
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
702
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

68.6K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
68.6K
Psychological Responses to Stress01:20

Psychological Responses to Stress

788
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
788

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lower-Body Strength, Lean Mass, and Bone Mineral Density Across the Adult Lifespan: Age- and Sex-Related Associations.

Medicine and science in sports and exercise·2026
Same author

Differential associations between subjective and objective physical activity and memory across adulthood: a specification curve analysis.

Scientific reports·2026
Same author

Exploring the relative contributions of multiple modifiable physical health variables to executive function and episodic memory performance in older adults.

Neuropsychology·2026
Same author

Divergent disinhibition profiles linked to externalizing psychopathology.

Journal of psychopathology and clinical science·2026
Same author

Cardiorespiratory fitness is differentially associated with motor cortex laterality in middle-aged and older adults.

Scientific reports·2026
Same author

Causal Effects of Enhanced Parenting on Resting-State Graph Properties of Adolescents at Risk for Maltreatment.

Biological psychiatry global open science·2026

Related Experiment Video

Updated: Mar 3, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.9K

Default Mode Network Subsystems are Differentially Disrupted in Posttraumatic Stress Disorder.

Danielle R Miller1,2, Scott M Hayes2,3,4, Jasmeet P Hayes3,4,5

  • 1Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|April 25, 2017
PubMed
Summary

Individuals with PTSD show altered default mode network connectivity, specifically in the medial temporal lobe subsystem. This disruption is linked to symptom severity, suggesting a key role in PTSD.

Keywords:
PTSDavoidancedefault mode networkfunctional connectivitymedial temporal loberesting state fMRI

More Related Videos

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

13.3K
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.9K

Related Experiment Videos

Last Updated: Mar 3, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.9K
Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

13.3K
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

16.9K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Posttraumatic stress disorder (PTSD) involves re-experiencing, avoidance, and hyperarousal symptoms.
  • PTSD is associated with disrupted functional connectivity in the default mode network (DMN).
  • The DMN comprises a midline core, medial temporal lobe (MTL), and dorsomedial prefrontal cortex (dMPFC) subsystems.

Purpose of the Study:

  • To investigate differential disruption of DMN subsystem functional connectivity in PTSD.
  • To determine if specific DMN subsystems are selectively affected in individuals with PTSD.

Main Methods:

  • Resting state functional MRI (rs-fMRI) was used in 69 Veterans with PTSD and 44 trauma-exposed controls.
  • Functional connectivity was examined using seed regions in DMN hubs (PCC, aMPFC) and subsystems.
  • Seed regions included PCC, aMPFC, and MTL/dMPFC subsystem hubs like vMPFC.

Main Results:

  • PTSD group showed reduced functional connectivity between PCC and hippocampus (MTL subsystem).
  • No group differences in PCC-dMPFC connectivity or aMPFC connectivity were found.
  • PCC-hippocampus connectivity negatively correlated with avoidance/numbing symptoms in PTSD.
  • Reduced anticorrelation between vMPFC and dACC observed in PTSD.

Conclusions:

  • Selective alterations in MTL subsystem connectivity are implicated in PTSD.
  • These functional connectivity changes may contribute to PTSD pathology and symptoms.