Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

4.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.1K
Antigen Presenting Cells01:22

Antigen Presenting Cells

3.8K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.8K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

17.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.4K
T Cell Types and Functions01:24

T Cell Types and Functions

2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

16.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
16.8K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.5K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CSF1R regulates monocyte subset differentiation and intracellular metabolism.

Nature communications·2026
Same author

Molecular and spatial specialization of lung interstitial macrophage subsets: beyond chemokines.

Frontiers in immunology·2026
Same author

Novel mouse models for perianal fistulizing Crohn's disease reveal therapeutic value of interferon-γ antagonists.

bioRxiv : the preprint server for biology·2026
Same author

Oxaliplatin triggers adipose and muscle wasting through cancer-independent metabolic and CNS pathways in mouse models.

Communications biology·2026
Same author

Oral [<sup>18</sup>F]-Fluoro-Thia-Heptadecanoic Acid Positron Emission Tomography Reveals Mesenteric-to-Central Lymphatic Flow.

Gastro hep advances·2026
Same author

Alveolar macrophage subtypes express cholesterol and inflammation genes in cystic fibrosis.

Life science alliance·2026
Same journal

A guide to CAR T cell therapies: development, current status and future prospects.

Nature reviews. Immunology·2026
Same journal

Macrophages in embryonic development.

Nature reviews. Immunology·2026
Same journal

Glycolytic capacity instructs tumour vasculature and response to immunotherapy.

Nature reviews. Immunology·2026
Same journal

Vaginal NK cells limit epithelial barrier disruption during infection.

Nature reviews. Immunology·2026
Same journal

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026
Same journal

T cell engagers in autoimmune diseases.

Nature reviews. Immunology·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

Author Spotlight: Dendritic Cells Maturation Using Sialidases-Based Enzymatic Treatment of the Cell Surface
13:36

Author Spotlight: Dendritic Cells Maturation Using Sialidases-Based Enzymatic Treatment of the Cell Surface

Published on: October 20, 2023

4.3K

Monocyte differentiation and antigen-presenting functions.

Claudia V Jakubzick1,2, Gwendalyn J Randolph3, Peter M Henson1,2

  • 1Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, Colorado 80206, USA.

Nature Reviews. Immunology
|April 25, 2017
PubMed
Summary
This summary is machine-generated.

Monocytes, crucial blood immune cells, develop into diverse tissue macrophages and act as antigen-presenting cells, revealing complex roles beyond their traditional functions.

More Related Videos

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols
08:31

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

Published on: October 18, 2016

14.3K
Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro
09:16

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

7.6K

Related Experiment Videos

Last Updated: Mar 3, 2026

Author Spotlight: Dendritic Cells Maturation Using Sialidases-Based Enzymatic Treatment of the Cell Surface
13:36

Author Spotlight: Dendritic Cells Maturation Using Sialidases-Based Enzymatic Treatment of the Cell Surface

Published on: October 20, 2023

4.3K
Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols
08:31

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

Published on: October 18, 2016

14.3K
Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro
09:16

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

7.6K

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Monocytes are the main mononuclear phagocytes in blood.
  • Traditionally viewed as precursors to tissue macrophages.
  • Emerging evidence suggests broader functions in circulation and tissues.

Purpose of the Study:

  • Review recent findings on monocyte maturation and function.
  • Explore monocyte-derived cell roles in tissues.
  • Discuss emerging roles in adaptive immunity.

Main Methods:

  • Literature review of current research on monocytes.
  • Synthesis of newer concepts in monocyte biology.
  • Analysis of monocyte functions in various immune contexts.

Main Results:

  • Monocytes differentiate into various macrophage subtypes.
  • Monocytes exhibit complex functions within blood and tissues.
  • Monocytes play a role in adaptive immunity as antigen-presenting cells.

Conclusions:

  • Monocyte roles are more complex than previously understood.
  • Monocyte differentiation leads to diverse tissue-specific functions.
  • Monocytes are key players in both innate and adaptive immunity.