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Visual complaints in intracranial germinomas.

Didier Frappaz¹, Claire Pedone¹, Philippe Thiesse²

¹Department of Oncology, Institut d'Hématologie et d'Oncologie Pédiatrique, Lyon, France.

Pediatric Blood & Cancer

|April 25, 2017

Summary

This summary is machine-generated.

Visual disturbances are common in patients with intracranial germinoma tumors (ICGTs). Optic pathway involvement is often underestimated, necessitating careful evaluation and adjusted radiotherapy for better outcomes.

Keywords:

germinoma relapse vision

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Area of Science:

Neuro-oncology
Ophthalmology
Radiology

Background:

Patients with brain tumors frequently experience visual complaints.
These symptoms can stem from increased intracranial pressure, optic pathway compression/invasion, or diplopia.

Purpose of the Study:

To determine the incidence and causes of visual symptoms in patients with intracranial germinoma tumors (ICGTs).

Main Methods:

A blinded retrospective review of clinical records and initial MRI scans was conducted for 28 ICGT patients.
Tumor locations included pineal, suprasellar, bifocal regions, optic nerve, corpus callosum, and brainstem.

Main Results:

Twelve patients reported visual disturbances, with seven experiencing decreased vision.
Optic pathway involvement was underestimated in two cases initially diagnosed as retrobulbar neuritis, leading to relapse.
Visual field deficits were permanent, while visual acuity sometimes improved without optic atrophy.

Conclusions:

Compression or invasion of the optic pathway by germinomas is a significant concern.
Early detection of optic pathway involvement through imaging is crucial.
Radiotherapy fields should be adjusted to encompass potential optic pathway compression.