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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Two cytotoxic 6,7-seco-spiro-lacton-ent-kauranoids from Isodon rubescens
Guo-Yong Luo1, Rui Deng1, Jing-Jie Zhang1
1a School of Pharmacy , Guiyang College of Traditional Chinese Medicine , Guiyang 550002 , China.
Abstract:
The present study was performed to investigate the chemical components of the branches and leaves of Isodon rubescens. Two 6,7-seco-spiro-lacton-ent-kauranoids were obtained. Based on the extensive spectroscopic analyses, their structures were elucidated as 6-epi-11-O-acetylangustifolin (1) and 11-O-acetylangustifolin (2), respectively. The structure of 2 was further comfirmed by X-ray crystallography analysis. MTT method was employed to evaluate their cytotoxity against human lung cancer cell lines A549 and leukemia cell lines K562.
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