A Bipartite Network and Resource Transfer-Based Approach to Infer lncRNA-Environmental Factor Associations

Phenotypes and diseases are often determined by the complex interactions between genetic factors and environmental factors (EFs). However, compared with protein-coding genes and microRNAs, there is a paucity of computational methods for understanding the associations between long non-coding RNAs (lncRNAs) and EFs. In this study, we focused on the associations between lncRNA and EFs. By using the common miRNA partners of any pair of lncRNA and EF, based on the competing endogenous RNA (ceRNA) hypothesis and the technique of resources transfer within the experimentally-supported lncRNA-miRNA and miRNA-EF association bipartite networks, we propose an algorithm for predicting new lncRNA-EF associations. Results show that, compared with another recently-proposed method, our approach is capable of predicting more credible lncRNA-EF associations. These results support the validity of our approach to predict biologically significant associations, which could lead to a better understanding of the molecular processes.