Should we administer oxygen during an acute coronary syndrome?

Oxygen therapy is used for the treatment of acute coronary syndrome without further discussion. However, the support of this practice in clinical research is scarce, ignoring the true effects of its implementation. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple information sources. We identified five systematic reviews including 12 studies overall, five of which were randomized trials. We extracted data, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We concluded that using oxygen probably does not decrease pain, and might not make any difference in mortality during an acute coronary syndrome.