Related Experiment Video
Updated: Mar 3, 2026
09:04
Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
Published on: February 20, 2018
13.0K
Irisin and musculoskeletal health
Graziana Colaianni1, Saverio Cinti2, Silvia Colucci1
1Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari, Bari, Italy.
Annals of the New York Academy of Sciences
|April 25, 2017
Summary
Exercise-induced irisin hormone may enhance bone mass and muscle strength. Studies suggest irisin could treat osteoporosis and muscle wasting, potentially benefiting bedridden patients.
Area of Science:
- Exercise physiology
- Endocrinology
- Musculoskeletal biology
Background:
- Irisin is a myokine released by skeletal muscle during exercise.
- It influences fat browning and thermogenesis.
- Potential roles beyond metabolism in the musculoskeletal system are explored.
Purpose of the Study:
- To review the evidence for irisin's effects on the musculoskeletal system.
- To examine irisin's role in bone mass regulation.
- To investigate irisin's autocrine effects on skeletal muscle.
Main Methods:
- Review of existing scientific literature on irisin.
- Analysis of studies investigating irisin's impact on bone density and geometry in mice.
- Examination of irisin's influence on its precursor, FNDC5, in skeletal muscle.
Main Results:
- Irisin positively affects cortical bone mineral density and geometry in mice.
- Irisin upregulates its precursor, FNDC5, in skeletal muscle (autocrine effect).
- Loss of bone and muscle mass is associated with aging, immobility, and metabolic diseases.
Conclusions:
- Irisin may play a crucial role in maintaining bone mass.
- Irisin could be a therapeutic target for osteoporosis and muscle wasting.
- Further human studies are needed to confirm efficacy for treating conditions in the physically disabled or bedridden.
More Related Videos
Related Concept Videos
01:22Connective Tissue Cell Types
4.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.4K
01:21EPS and iPS Cells in Disease Research
3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K
01:21Satellite Stem Cells and Muscular Dystrophy
2.5K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.5K