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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using

Michael D Aleo1, Falgun Shah2, Kan He3

  • 1Drug Safety Research and Development, Pfizer Inc. , Groton, Connecticut 06340, United States.

Chemical Research in Toxicology
|April 25, 2017
PubMed
Summary

Drug-induced liver injury (DILI) can involve inhibition of the multidrug resistant protein 3 (MDR3), which affects phospholipid secretion. Compounds inhibiting both MDR3 and bile salt export protein (BSEP) may pose higher DILI risks.

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