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Effect of Using the HEART Score in Patients With Chest Pain in the Emergency Department: A Stepped-Wedge, Cluster
Judith M Poldervaart1, Johannes B Reitsma1, Barbra E Backus1
1From University Medical Center Utrecht and Diakonessenhuis Utrecht, Utrecht; University of Twente, Enschede; Medical Center The Hague, The Hague; Vu University Medical Center, Amsterdam; Amstelland Hospital, Amstelveen; Catharina Hospital, Eindhoven; St. Antonius Hospital, Nieuwegein; Zuyderland Hospital, Heerlen; Gelderse Vallei Hospital, Ede; Tergooi Hospital, Hilversum; Groene Hart Hospital, Gouda; Meander Medical Center, Amersfoort; Radboud University Medical Center, Nijmegen; Maastricht University Medical Center, Maastricht; Gelre Hospital, Apeldoorn; and Zuwe Hofpoort Hospital, Woerden, the Netherlands.
Insights
The HEART score is safe for assessing chest pain patients, reducing major adverse cardiac events. However, its impact on healthcare resource use was limited, possibly due to physician adherence issues.
Area of Science:
- Cardiology
- Clinical Decision Support
- Health Services Research
Background:
- The HEART score aids in stratifying chest pain patients by short-term risk of major adverse cardiac events (MACEs).
- Its real-world impact on clinical practice and healthcare resource utilization remained unclear.
Purpose of the Study:
- To evaluate the effect of implementing the HEART score on patient outcomes.
- To assess the impact of the HEART score on healthcare resource utilization.
Main Methods:
- A stepped-wedge, cluster randomized trial was conducted across 9 Dutch emergency departments.
- Unselected chest pain patients were managed with usual care or HEART score-guided care over 2013-2014.
- A noninferiority margin of 3.0% absolute increase in MACEs within 6 weeks was set for safety.
Main Results:
- The 6-week MACE incidence was 1.3% lower with HEART score use compared to usual care, remaining within the noninferiority margin.
- In low-risk patients, MACE incidence was 2.0%.
- No significant differences were found in early discharge, readmissions, or healthcare visits.
Conclusions:
- The HEART score is a safe tool for initial chest pain assessment.
- Limited impact on healthcare resource use was observed, potentially due to physician hesitancy in adhering to HEART score recommendations for low-risk patients.
Background:
The HEART (History, Electrocardiogram, Age, Risk factors, and initial Troponin) score is an easy-to-apply instrument to stratify patients with chest pain according to their short-term risk for major adverse cardiac events (MACEs), but its effect on daily practice is unknown.
Objective:
To measure the effect of use of the HEART score on patient outcomes and use of health care resources.
Design:
Stepped-wedge, cluster randomized trial. (ClinicalTrials.gov: NCT01756846).
Setting:
Emergency departments in 9 Dutch hospitals.
Patients:
Unselected patients with chest pain presenting at emergency departments in 2013 and 2014.
Intervention:
All hospitals started with usual care. Every 6 weeks, 1 hospital was randomly assigned to switch to "HEART care," during which physicians calculated the HEART score to guide patient management.
Measurements:
For safety, a noninferiority margin of a 3.0% absolute increase in MACEs within 6 weeks was set. Other outcomes included use of health care resources, quality of life, and cost-effectiveness.
Results:
A total of 3648 patients were included (1827 receiving usual care and 1821 receiving HEART care). Six-week incidence of MACEs during HEART care was 1.3% lower than during usual care (upper limit of the 1-sided 95% CI, 2.1% [within the noninferiority margin of 3.0%]). In low-risk patients, incidence of MACEs was 2.0% (95% CI, 1.2% to 3.3%). No statistically significant differences in early discharge, readmissions, recurrent emergency department visits, outpatient visits, or visits to general practitioners were observed.
Limitation:
Physicians were hesitant to refrain from admission and diagnostic tests in patients classified as low risk by the HEART score.
Conclusion:
Using the HEART score during initial assessment of patients with chest pain is safe, but the effect on health care resources is limited, possibly due to nonadherence to management recommendations.
Primary Funding Source:
Netherlands Organisation for Health Research and Development.
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