Related Experiment Video
Updated: Mar 3, 2026
10:44
Influenza A Virus Studies in a Mouse Model of Infection
Published on: September 7, 2017
30.0K
H3N2 Canine Influenza Virus Infection in a Dog.
C E Watson1,2, C Bell1,2, K Toohey-Kurth1,2
11 Wisconsin Veterinary Diagnostic Laboratory, University of Wisconsin-Madison, Madison, WI, USA.
Veterinary Pathology
|April 26, 2017
Summary
A fatal case of H3N2 canine influenza in a German Shepherd is detailed. The study identified the novel North American strain, revealing severe respiratory lesions and co-infections in the dog.
Area of Science:
- Veterinary Pathology
- Molecular Virology
- Canine Infectious Diseases
Background:
- Canine influenza virus (CIV) H3N2 emerged in Chicago in 2015.
- Early identification and characterization of novel viral strains are crucial for canine health.
- Understanding co-infections is vital for effective treatment strategies.
Observation:
- A 10-year-old German Shepherd presented with severe lethargy and coughing, rapidly progressing to death.
- Necropsy revealed fibrinonecrotic membranes in the larynx, pharynx, and trachea.
- Lungs exhibited multifocal necrosis, hemorrhage, congestion, and pulmonary edema.
Findings:
- Canine influenza virus (CIV) H3N2 was identified, with viral neuraminidase gene sequence showing ≥98% homology to the circulating Chicago strain.
- Staphylococcus pseudointermedius was isolated from lung tissue.
- Mycoplasma cynos was detected via real-time polymerase chain reaction in multiple respiratory tract locations.
Implications:
- This case highlights the severe pathogenicity of the novel H3N2 canine influenza strain.
- Concurrent bacterial and Mycoplasma infections complicate canine influenza cases.
- Accurate molecular diagnostics are essential for identifying emerging canine respiratory pathogens.
