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Isolation and characterization of a variant form of vasoactive intestinal polypeptide
G Gafvelin1, M Andersson, R Dimaline
1Department of Biochemistry II and Chemistry I, Karolinska Institute, Stockholm, Sweden.
Peptides
|May 1, 1988
Abstract:
A variant form of the vasoactive intestinal polypeptide (VIP) has been isolated. It was found to consist of a molecule which instead of the C-terminal asparagine amide of VIP has a C-terminal extension of Gly-Lys-Arg. This VIP variant displaces VIP in a VIP receptor assay, reacts with N-terminally-directed antisera in a VIP radioimmunoassay and possesses VIP-like bioactivity in an assay measuring pancreatic juice secretion in the cat.