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Related Concept Videos

Enzyme-linked Receptors01:00

Enzyme-linked Receptors

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Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
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Enzyme-Linked Immunosorbent Assay01:33

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In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or...
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Transducer Mechanism: Enzyme-Linked Receptors01:27

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
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Classification of Systems-II01:31

Classification of Systems-II

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Continuous-time systems have continuous input and output signals, with time measured continuously. These systems are generally defined by differential or algebraic equations. For instance, in an RC circuit, the relationship between input and output voltage is expressed through a differential equation derived from Ohm's law and the capacitor relation,
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Statistical Analysis System (SAS)01:14

Statistical Analysis System (SAS)

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SAS, short for Statistical Analysis System, is a powerful data analysis, management, and visualization tool. Developed by the SAS Institute in the early 1970s, SAS has evolved into a comprehensive software suite used across various industries for statistical analysis, business intelligence, and predictive modeling.
Applications: SAS finds applications in numerous fields, including healthcare for clinical trial analysis, finance for risk assessment, marketing for customer data analysis, and...
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Nursing Clinical Information System01:27

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Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
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Related Experiment Video

Updated: Mar 3, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

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The BRENDA enzyme information system-From a database to an expert system.

I Schomburg1, L Jeske1, M Ulbrich1

  • 1Technische Universität Braunschweig, Braunschweig Integrated Centre of Systems Biology (BRICS), Rebenring 56, 38106 Braunschweig, Germany.

Journal of Biotechnology
|April 26, 2017
PubMed
Summary

The BRaunschweig ENzyme DAtabase (BRENDA) is a vital resource for enzyme information. It provides comprehensive data on enzyme functions and properties, supporting research and applications in biotechnology and medicine.

Keywords:
Enzyme databaseEnzyme kineticsEnzyme-catalysed reactionsEnzyme-ligand interactionEnzymes and diseasesMetabolic pathways

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A Protocol for Computer-Based Protein Structure and Function Prediction
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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Molecular Biology

Background:

  • Enzymes are crucial proteins involved in essential life processes like metabolism and gene expression.
  • Enzyme dysfunction is linked to numerous diseases, making them key targets for medical research and diagnostics.
  • The BRaunschweig ENzyme DAtabase (BRENDA) centralizes enzyme data for the scientific community.

Purpose of the Study:

  • To describe the data content, acquisition, and integration processes of the BRENDA database.
  • To outline methods for accessing and visualizing enzyme data within BRENDA.
  • To highlight BRENDA's significance as a widely used biological database.

Main Methods:

  • Data collection and integration from various sources.
  • Quality control and curation of enzyme functional parameters and properties.
  • Development of user-friendly web interfaces for data access and visualization.

Main Results:

  • BRENDA has become a leading global biological database over 30 years.
  • The database offers extensive information on enzyme functions, properties, and related research.
  • The website provides diverse tools for data exploration and analysis.

Conclusions:

  • BRENDA is an indispensable resource for researchers in enzymology, biotechnology, and medicine.
  • The database facilitates advancements in understanding enzyme roles and developing new applications.
  • Continuous updates and user accessibility ensure BRENDA's ongoing value to science.