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Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

Marcel Klingenberg1, Akiko Matsuda2, Sven Diederichs3

  • 1Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology (HBIGS), University of Heidelberg, Heidelberg, Germany.

Journal of Hepatology
|April 26, 2017
PubMed

Insights

Non-coding RNAs (ncRNAs), transcribed from the human genome, play a role in liver cancer development. This review explores ncRNA functions and their potential for early detection and novel treatments in liver cancer.

Area of Science:

  • Genomics
  • Molecular Biology
  • Oncology

Background:

  • The human genome extensively transcribes non-coding RNAs (ncRNAs).
  • ncRNAs do not produce proteins but are implicated in disease pathogenesis.
  • ncRNAs are increasingly recognized for their roles in various cancers.

Purpose of the Study:

  • To review the functions of ncRNAs in liver cancer.
  • To explore the potential of ncRNAs in liver cancer detection.
  • To discuss the therapeutic applications of ncRNAs in liver cancer.

Main Methods:

  • Literature review of ncRNA functions in liver cancer.
  • Analysis of studies on ncRNA-based biomarkers for detection.
  • Examination of research on ncRNA-targeted therapies.

Main Results:

  • ncRNAs exhibit diverse regulatory roles in liver cancer initiation and progression.
  • Specific ncRNAs show promise as sensitive and specific biomarkers for early liver cancer detection.
  • ncRNAs represent viable targets for novel therapeutic strategies against liver cancer.

Conclusions:

  • ncRNAs are critical players in liver cancer biology.
  • ncRNAs offer significant potential for improving liver cancer diagnostics.
  • Targeting ncRNAs may lead to effective new treatments for liver cancer.
Keywords:
Cancer stem cellEpithelial–to-mesenchymal transitionHCCHepatocellular carcinomaLiver cancerLong non-coding RNASTAT3WntlncRNAmicroRNA

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