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Nuclear receptor research in zebrafish.

Marcel J M Schaaf¹

¹Institute of Biology (IBL)Leiden University, Leiden, The Netherlands m.j.m.schaaf@biology.leidenuniv.nl.

Journal of Molecular Endocrinology

|April 26, 2017

Summary

Zebrafish models offer valuable insights into nuclear receptors (NRs), a crucial class of ligand-activated transcription factors. This review highlights zebrafish research on estrogen receptors, retinoic acid receptors, and PPARs, showcasing their utility in various scientific fields.

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Area of Science:

Endocrinology and Molecular Biology
Comparative Genomics
Toxicology

Background:

Nuclear receptors (NRs) are essential ligand-activated transcription factors regulating diverse physiological processes.
NRs are highly conserved across vertebrate species, with zebrafish possessing 73 NR genes, including orthologues for most human NRs.
The zebrafish is an emerging model organism for studying NRs due to its genetic conservation and suitability for research.

Purpose of the Study:

To provide an overview of nuclear receptor research utilizing the zebrafish model.
To review studies on three prominent zebrafish NRs: estrogen receptors (ERs), retinoic acid receptors (RARs), and peroxisome proliferator-activated receptors (PPARs).
To illustrate the versatility of zebrafish in ecotoxicological, developmental, and biomedical research concerning NRs.

Keywords:

estrogen receptor nuclear receptor peroxisome proliferator-activated receptor retinoic acid receptor zebrafish

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Main Methods:

Literature review of published research on zebrafish nuclear receptors.
Focus on studies involving estrogen receptors (ERs), retinoic acid receptors (RARs), and peroxisome proliferator-activated receptors (PPARs) in zebrafish.
Analysis of zebrafish model applications in ecotoxicology, developmental biology, and biomedical research.

Main Results:

Zebrafish possess a comprehensive set of NR genes, mirroring human counterparts.
Research on zebrafish ERs, RARs, and PPARs demonstrates their utility in understanding NR function.
Studies highlight zebrafish's applicability in ecotoxicological, developmental, and biomedical NR research.

Conclusions:

The zebrafish is a versatile and valuable model system for nuclear receptor research.
Despite current limitations, the potential of zebrafish in NR studies is expected to grow significantly.
Zebrafish research contributes to understanding NR roles in physiology, development, and environmental health.