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Targeted therapies in breast cancer: New challenges to fight against resistance

Viviana Masoud1, Gilles Pagès1

  • 1Viviana Masoud, Gilles Pagès, University Nice Sophia Antipolis, Institute for Research on Cancer and Aging of Nice CNRS UMR7284/INSERM U 1081, 06189 Nice, France.

World Journal of Clinical Oncology
|April 26, 2017
PubMed

Insights

Breast cancer targeted therapies are advancing, but drug resistance remains a challenge. This review explores emerging molecular resistance mechanisms and strategies to overcome them, aiming to improve patient survival.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunotherapy

Background:

  • Breast cancer is a leading public health concern, particularly among women.
  • Recent advances in molecular biology and immunotherapy have led to targeted therapies for specific breast cancer subtypes.
  • Despite progress, therapeutic resistance remains a significant obstacle in breast cancer treatment.

Purpose of the Study:

  • To review emerging molecular resistance mechanisms in breast cancer targeted therapy.
  • To discuss strategies for circumventing therapeutic resistance.
  • To provide an update on recent developments and future prospects for preventing resistance.

Main Methods:

  • Literature review of recent developments in breast cancer targeted therapy.
  • Analysis of molecular resistance mechanisms.
  • Discussion of potential strategies to overcome resistance.

Main Results:

  • Identification of various emerging molecular resistance mechanisms in breast cancer.
  • Exploration of potential therapeutic strategies to combat resistance.
  • Highlighting the need for further research into resistance pathways.

Conclusions:

  • Understanding and overcoming therapeutic resistance is crucial for improving breast cancer patient outcomes.
  • Future research should focus on novel strategies to prevent or reverse resistance.
  • Continued advancements in targeted therapies require parallel investigation into resistance mechanisms.
Keywords:
AngiogenesisBreast cancersHuman epidermal growth factor receptor 2Immune toleranceResistanceTriple negative

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