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Published on: March 21, 2021
Circulating cell-free nucleic acids as potential biomarkers for sarcopenia: a step toward personalized medicine
Gita Shafiee1, Ramin Heshmat1, Bagher Larijani2
1Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Dr shariati hospital, north karegar st, Tehran, 14114 Iran.
Abstract:
Sarcopenia is an age-related loss of muscle mass and function, leading to disability, morbidity and increased mortality in older people. Given the relatively high prevalence and related- outcome of the disease, correct diagnosis, screening, monitoring and treatment of sarcopenia are needed in clinical practice. Recent researches have focused on cell-free nucleic acids, which are released into the circulation following cell death, as a potential biomarker of aging and systematic inflammation. It seems that the diagnosis and treatment of sarcopenia can be possible by the help of the analysis of cell-free nucleic acids as noninvasive method.
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