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Catestatin and orexin-A influence hamster thermic states during hibernation
Maria Mele1, Marcello Canonaco1
1Comparative Neuroanatomy Laboratory; Biology, Ecology & Earth Science Department (DiBEST); University of Calabria; Arcavacata di Rende, CS Italy.
Temperature (Austin, Tex.)
|April 26, 2017
Abstract:
Decreased body temperature during hibernation evokes a neuroprotective effect against the frequent neurodegenerative events of ischemic/reperfusion injuries. This neuroprotection appears to stem from a direct involvement of orexin-A plus the sympathoinhibitory neuroactive peptide catestatin on orexin 2 receptor-dependent feeding and motor behaviors of the facultative hibernating hamster.
Keywords:
Mesocricetus auratusanorexigenicchromogranin-A derivativehypothermiaorexigenicneuroprotectionorexin 2 receptormetabolic depressionischemic injury
