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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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CKS1BP7, a Pseudogene of CKS1B, is Co-Amplified with IGF1R in Breast Cancers

Yansong Liu1, Wei Wang2, Yan Li3

  • 1Department of Breast Surgery, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong, 250117, People's Republic of China.

Pathology Oncology Research : POR
|April 26, 2017
PubMed

Insights

Copy number alterations of the CKS1B pseudogene 7 (CKS1BP7) are frequent in breast cancer and often co-occur with amplified insulin-like growth factor 1 receptor (IGF1R). These findings suggest CKS1BP7 and IGF1R roles in mammary carcinogenesis.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Pseudogenes, once considered non-functional, are increasingly recognized for their roles in biological processes.
  • Overexpression of CDC28 protein kinase regulatory subunit 1B (CKS1B) is implicated in various human cancers.
  • The functional significance of CKS1B pseudogene 7 (CKS1BP7), despite its sequence similarity to CKS1B, remains largely unexplored in breast cancer.

Purpose of the Study:

  • To investigate copy number alterations (CNAs) of CKS1BP7 in breast cancer.
  • To explore the potential roles of CKS1BP7 in breast cancer development and progression.
  • To assess the relationship between CKS1BP7 CNAs, insulin-like growth factor 1 receptor (IGF1R) status, tumor characteristics, and patient outcomes.

Main Methods:

  • Quantitative multi-gene fluorescence in situ hybridization (QM-FISH) was employed to detect copy numbers of CKS1BP7 and IGF1R.
  • Analysis was performed on both ductal carcinoma in situ (DCIS) and invasive carcinoma components within the same tumor samples.
  • Associations between gene CNAs, tumor features (aneuploidy, Ki67 expression), and patient prognosis were examined.

Main Results:

  • CKS1BP7 amplification (dot-like pattern) was detected in 28.8% of breast cancer cases.
  • IGF1R amplification (cluster pattern) was identified in 24.2% of cases, frequently co-occurring with CKS1BP7 amplification (p=0.01).
  • Identical CNAs for CKS1BP7 and IGF1R were observed in both DCIS and invasive components; amplifications were more common in aneuploid tumors with high Ki67 but did not correlate with patient outcomes.

Conclusions:

  • CKS1BP7 amplification is a frequent event in breast cancer, often co-occurring with IGF1R amplification, suggesting potential interactions during mammary carcinogenesis.
  • The findings support CKS1BP7 and IGF1R as potential biomarkers for early breast cancer detection.
  • Both CKS1BP7 and IGF1R may serve as prognostic indicators in breast cancer patients.
Keywords:
Breast cancerCKS1BP7IGF1RQuantitative multi-gene fluorescence in situ hybridization

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