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Updated: Mar 3, 2026

Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy
Published on: October 24, 2025
Neuromonitoring in endoscopic and robotic thyroidectomy.
Gianlorenzo Dionigi1, Hoon Yub Kim2, Che-Wei Wu3,4
11st Division of General Surgery, Research Center for Endocrine Surgery, Department of Medicine and Surgery, ASST Sette Laghi Ospedale di Circolo e Fondazione Macchi - Polo Universitario, University of Insubria (Varese-Como), via Guicciardini 9, 21100, Varese, Italy.
Intraoperative neuromonitoring (IONM) is effective in conventional thyroid surgery. This review assesses its use in endoscopic and robotic thyroidectomy, finding limited studies but promising low rates of recurrent laryngeal nerve palsy.
Area of Science:
- Surgical Technology
- Neurosurgery
- Endocrinology
Background:
- Intraoperative neuromonitoring (IONM) is established for recurrent laryngeal nerve (RLN) function verification in conventional thyroid surgery.
- A systematic assessment of IONM in newer endoscopic and robotic thyroidectomy techniques was lacking.
Purpose of the Study:
- To systematically review and assess the evidence for intraoperative neuromonitoring (IONM) in endoscopic and robotic thyroidectomy.
- To evaluate the safety and efficacy of IONM in these minimally invasive procedures.
Main Methods:
- Systematic literature review using evidence-based criteria (2000-2015).
- Searched four databases (CENTRAL, MEDLINE, Cochrane, EMBASE) for studies on endoscopic/robotic thyroidectomy and IONM.
- Extracted data on study design, population, intervention, quality, and outcomes.
Main Results:
- Only 9% of 160 retrieved studies utilized IONM in endoscopic or robotic thyroidectomy.
- IONM was used in 522 nerves at risk across eight studies, with only three prospective randomized trials.
- Recurrent laryngeal nerve palsy rates were low: 0-3.6% transient and 0-0.4% permanent.
Conclusions:
- IONM is a valuable assistive technology for navigating complex endoscopic and robotic thyroidectomy procedures.
- IONM demonstrates potential as a routine adjunct for nerve identification, similar to conventional thyroid surgery.
- Further research is needed to establish standardized protocols for IONM in minimally invasive thyroid surgery.
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