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The molecular orbital theory describes the distribution of electrons in molecules in a manner similar to the distribution of electrons in atomic orbitals. The region of space in which a valence electron in a molecule is likely to be found is called a molecular orbital. Mathematically, the linear combination of atomic orbitals (LCAO) generates molecular orbitals. Combinations of in-phase atomic orbital wave functions result in regions with a high probability of electron density, while...
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Covalent bonds are formed between two atoms when both have similar tendencies to attract electrons to themselves (i.e., when both atoms have identical or fairly similar ionization energies and electron affinities). Nonmetal atoms frequently form covalent bonds with other nonmetal atoms. For example, the hydrogen molecule, H2, contains a covalent bond between its two hydrogen atoms. When two separate hydrogen atoms with a particular potential energy approach each other, their valence orbitals...
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Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
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Antiparallel Dynamic Covalent Chemistries.

Bartosz M Matysiak1,2, Piotr Nowak1, Ivica Cvrtila1

  • 1Centre for Systems Chemistry, Stratingh Institute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Journal of the American Chemical Society
|April 26, 2017
PubMed
Summary
This summary is machine-generated.

We introduce antiparallel chemistries, enabling control over complex chemical systems. This approach uses reversible thiol-disulfide exchange and thio-Michael addition reactions for dynamic control.

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Area of Science:

  • Chemical Systems
  • Supramolecular Chemistry
  • Organic Chemistry

Background:

  • Designing complex functional chemical systems requires controllable reaction networks.
  • Dynamic combinatorial chemistry offers complexity but lacks precise control.
  • Advanced systems chemistry demands methods for both generating and addressing complexity.

Purpose of the Study:

  • Introduce antiparallel chemistries for controllable complexity in chemical systems.
  • Demonstrate a system switching between thiol-disulfide exchange and thio-Michael addition.
  • Provide a versatile platform for developing advanced functional chemical systems.

Main Methods:

  • Utilized antiparallel chemistries: thiol-disulfide exchange and thio-Michael addition.
  • Employed a common thiol building block for both reversible chemistries.
  • Controlled the system's state via oxidation and reduction parameters.

Main Results:

  • Achieved reversible switching between thio-Michael addition and disulfide formation.
  • Demonstrated control over the degree of each chemistry via redox potential.
  • Showcased the system's operation in aqueous media at room temperature and mild pH.

Conclusions:

  • Antiparallel chemistries offer a novel strategy for designing addressable complex chemical systems.
  • The thiol-based system provides a robust platform for systems chemistry development.
  • This approach facilitates the creation of dynamic functional materials and molecular devices.