Massive nasal polyposis in a patient with newly diagnosed cystic fibrosis

Cystic fibrosis (CF) - is the most common fatal autosomal recessive disease in Caucasians. A number of reports have described patients who do not meet diagnostic criteria for cystic fibrosis. Atypical or nonclassic CF is characterised by normal or borderline sweat test, pancreatic sufficiency and a monosymptomatic phenotype. For these reasons clinicians should remain alert to the possibility of the occurrence of CF.

We described a case presentation of massive nasal polyposis and recurrent sinusitis leading to the diagnosis ofcystic fibrosis in a 11-year-old male.

Our study indicates that chronic sinusitis and/or polyposis should raise the clinicians suspicion of a potential presentation of undiagnosed CF and require further investigations.