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Epigenetic modulators of thyroid cancer.
Sandra Rodríguez-Rodero1, Elías Delgado-Álvarez2, Lucía Díaz-Naya2
1Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain; Cancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, Spain.
Endocrinologia, Diabetes Y Nutricion
|April 26, 2017
Summary
Epigenetic factors, like DNA methylation and non-coding RNAs, play a role in thyroid cancer development. These epigenetic modulators offer potential for improved diagnosis and treatment strategies for thyroid carcinoma.
Area of Science:
- Endocrinology
- Oncology
- Epigenetics
Background:
- Established risk factors for thyroid cancer include iodine deficiency, early-life radiation exposure, and genetic alterations.
- Emerging research highlights the significant role of epigenetic modifications in thyroid tumorigenesis.
Purpose of the Study:
- To review the current understanding of epigenetic modulators in thyroid cancer.
- To explore the potential of epigenetic changes for diagnosis and treatment of thyroid carcinoma.
Main Methods:
- Literature review of epigenetic alterations in thyroid cancer.
- Analysis of changes in DNA methylation, histone modifications, and non-coding RNAs.
- Categorization of findings by thyroid carcinoma subtype.
Main Results:
- Specific DNA methylation patterns are associated with different types of thyroid cancer.
- Histone modifications are implicated in the dysregulation of genes crucial for thyroid cell function.
- Non-coding RNAs, including microRNAs and long non-coding RNAs, exhibit altered expression in thyroid tumors.
Conclusions:
- Epigenetic mechanisms are critical contributors to thyroid cancer etiology.
- Epigenetic markers hold promise as diagnostic biomarkers and therapeutic targets for thyroid cancer.
- Further research into epigenetic modulators could revolutionize thyroid cancer management.
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