[Early neonatal sepsis and associated factors]

Area of Science:

• Neonatal Medicine
• Infectious Diseases
• Pediatrics

Background:

• Early-onset neonatal sepsis (EONS) presents a significant threat to newborns, characterized by high morbidity and mortality.
• Identifying risk factors for EONS is crucial for prompt treatment and effective preventive strategies.

Purpose of the Study:

• To identify risk factors associated with early-onset neonatal sepsis (EONS).
• To provide data for timely treatment and preventive measures for EONS.

Main Methods:

• A case and control study design was employed over three years.
• Newborns were diagnosed with EONS via blood culture.
• Risk factors including gestational age, maternal infections, and premature rupture of membranes were analyzed.

Main Results:

• Maternal infection (OR 1.76), respiratory distress syndrome (OR 4.72), need for resuscitation (OR 2.9), intubation (OR 5.1), and ventilation support (OR 2.6) were statistically significant risk factors for EONS (p < 0.05).
• Staphylococcus coagulase-negative was the most frequently isolated microorganism (42.3%).

Conclusions:

• Maternal infection, need for resuscitation, and intubation for ventilation support are significant risk factors for EONS.
• These findings aid in developing targeted interventions for EONS prevention and management.