Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

6.0K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
6.0K
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

4.3K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
4.3K
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

1.4K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.4K
Autophagic Cell Death01:18

Autophagic Cell Death

4.8K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.8K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

10.4K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
10.4K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

410
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
410

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the Association between Age, Sex and d-Amino Acid-Based Estimation of Glomerular Filtration Rate.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Characteristics of newly diagnosed systemic lupus erythematosus patients with or without kidney involvement: analysis of the National Database of Designated Intractable Diseases of Japan.

Clinical and experimental nephrology·2026
Same author

Selective autophagy receptors: Multifunctional regulators of organelle turnover.

Current opinion in cell biology·2026
Same author

Epidemiological analysis of kidney involvement in systemic lupus erythematosus using the national database of designated intractable diseases of Japan: a cross-sectional study of renewal applicants.

Clinical and experimental nephrology·2026
Same author

Autophagy-Independent Function of ATG-18 Is Essential for Gonadal Longevity in Caenorhabditis elegans.

Aging cell·2026
Same author

Molecular mechanisms of the lysosomal damage response and its roles in aging and disease.

Journal of cell science·2025

Related Experiment Video

Updated: Mar 3, 2026

Rapid Depletion of Renal Macrophages Using Human CD59/Intermedilysin Cell Ablation Tool
10:15

Rapid Depletion of Renal Macrophages Using Human CD59/Intermedilysin Cell Ablation Tool

Published on: May 9, 2025

761

Autophagy and kidney inflammation.

Tomonori Kimura1, Yoshitaka Isaka1, Tamotsu Yoshimori2,3

  • 1a Department of Nephrology , Osaka University , Suita , Japan.

Autophagy
|April 26, 2017
PubMed
Summary
This summary is machine-generated.

Autophagy, a cellular process, protects kidneys from inflammation and damage. Modulating autophagy shows promise for treating kidney diseases and aging-related inflammation.

Keywords:
acute kidney injuryagingautoimmune diseaseautophagychronic kidney diseasecytokinediabetesend-stage kidney diseaseinflammationinnate immunitykidneylysosomemitochondriasepsis

More Related Videos

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

2.2K
Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry
07:14

Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry

Published on: October 18, 2016

15.5K

Related Experiment Videos

Last Updated: Mar 3, 2026

Rapid Depletion of Renal Macrophages Using Human CD59/Intermedilysin Cell Ablation Tool
10:15

Rapid Depletion of Renal Macrophages Using Human CD59/Intermedilysin Cell Ablation Tool

Published on: May 9, 2025

761
Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

2.2K
Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry
07:14

Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry

Published on: October 18, 2016

15.5K

Area of Science:

  • Cellular Biology
  • Nephrology
  • Immunology

Background:

  • Inflammation is central to kidney disease pathology.
  • Macroautophagy/autophagy influences inflammatory responses.
  • Autophagy's role in kidney inflammation is increasingly recognized.

Purpose of the Study:

  • To review the multifaceted roles of autophagy in kidney diseases and aging.
  • To explore autophagy's regulatory function in both kidney-specific and systemic inflammation.
  • To discuss the therapeutic potential of autophagy modulation for kidney inflammatory conditions.

Main Methods:

  • Literature review of studies on autophagy, inflammation, and kidney disease.
  • Analysis of research on autophagy's protective mechanisms in various kidney insults.
  • Examination of autophagy's role in systemic inflammation affecting the kidney.

Main Results:

  • Autophagy protects kidneys against acute, chronic, metabolic, and aging-related inflammatory insults.
  • Mitophagy and lysosome removal by autophagy are active in the kidney, suppressing inflammation.
  • Autophagy regulates systemic inflammation that impacts kidney health.

Conclusions:

  • Autophagy plays a critical protective role in the kidney by modulating inflammation.
  • Targeting autophagy offers a promising therapeutic strategy for inflammatory kidney diseases.
  • Understanding autophagy's mechanisms is key to developing novel treatments for kidney disorders.