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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Positron Emission Tomography01:29

Positron Emission Tomography

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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X-ray Imaging01:24

X-ray Imaging

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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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Related Experiment Video

Updated: Mar 3, 2026

In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy
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Skeletal Scintigraphy.

Jaime L Montilla-Soler1, Rikesh Makanji

  • 1Department of Radiology, Moffitt Cancer Center, Tampa, FL. Jaime.MontillaSoler@Moffitt.org.

Cancer Control : Journal of the Moffitt Cancer Center
|April 26, 2017
PubMed
Summary

Skeletal scintigraphy is crucial for evaluating bone cancers and metastases. Advances in radiopharmaceuticals and imaging techniques significantly improve the detection and management of skeletal metastatic disease.

Area of Science:

  • Nuclear medicine
  • Oncology
  • Radiology

Background:

  • Skeletal scintigraphy is a key diagnostic tool for primary and metastatic bone neoplasms.
  • It aids in the initial and ongoing assessment of the skeletal system in cancer patients.

Purpose of the Study:

  • To review radiopharmaceuticals, nuclear medicine imaging, and oncological applications for skeletal metastases in adults.
  • To discuss the advantages and limitations of current and future technologies for evaluating skeletal metastatic disease.

Main Methods:

  • Literature review of pertinent studies on skeletal scintigraphy and metastatic disease.
  • Discussion of nuclear medicine and positron emission tomography techniques for skeletal evaluation.

Main Results:

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  • Skeletal scintigraphy effectively identifies osteoblastic bone metastases.
  • Advancements in radiopharmaceuticals (e.g., fludeoxyglucose F 18, sodium fluoride F 18) and imaging (e.g., PET/CT, PET/MRI) enhance detection accuracy.

Conclusions:

  • Skeletal scintigraphy plays a vital role in cancer diagnosis, staging, and treatment monitoring for skeletal diseases.
  • Combined diagnostic and therapeutic nuclear agents show promise for treating bone metastases, particularly in prostate cancer, with potential for broader application.