Related Experiment Video
Updated: Mar 3, 2026

Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
Published on: January 20, 2023
It's T Time for Normal Blood Vessels
Bernard Thienpont1, Diether Lambrechts1
1Center for Cancer Biology, VIB, 3000 Leuven, Belgium; Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
Abstract:
In a new report in Nature, Tian and colleagues (2017) describe that T cell activation in tumors induces blood vessel normalization. Because abnormal vasculature in tumors is known to reduce chemotherapy effectiveness and T lymphocyte infiltration and to increase metastasis, this suggests an exciting novel angle for checkpoint immunotherapy.
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