Chemical constituents and biological activities from branches of Colubrina asiatica
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Published on: February 2, 2024
Watchara Sangsopha1, Kwanjai Kanokmedhakul1, Ratsami Lekphrom1
1a Natural Products Research Unit, Faculty of Science, Department of Chemistry, and Center for Innovation in Chemistry , Khon Kaen University , Khon Kaen , Thailand.
Abstract:
Sixteen compounds were isolated from a Thai medicinal plant, Colubrina asiatica. The isolated compounds were elucidated on the basis of spectroscopic methods (IR, 1D and 2D NMR) as six triterpene acids (1-6), five steroids (7-11), one benzoic acid derivative (12), two peptides (13 and 14), one sesquiterpenoid (15) and one jujubogenin (16). Compounds 3 and 10 showed antimalarial activity against Plasmodium falciparum. Compound 5 showed antimycobacterial activity. Moreover, compounds 3, 5, 6, 10 and 14 exhibited weak cytotoxicity against cancer cell lines. Compounds 1-15 have been isolated for the first time from this plant.
