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Updated: Mar 3, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
Acquired hemophilia A: a review of recent data and new therapeutic options
Massimo Franchini1,2, Stefania Vaglio1,3, Giuseppe Marano1
1a Italian National Blood Centre, National Institute of Health , Rome , Italy.
Objectives:
Acquired hemophilia A (AHA) is a rare, but potentially life-threatening, bleeding disorder caused by an autoantibody against factor VIII that interferes with its coagulant function.
Methods:
We performed a narrative review focusing on the diagnostic aspects of AHA and on the current treatment strategies with particular regard to new data and therapeutic developments.
Results:
The management of this severe hemorrhagic disorder is based on the control of bleeding with the use of bypassing agents and on the utilization of a variety of immunosuppressant agents with the goal of eliminating the autoantibody permanently.
Conclusion:
The optimal management of AHA should be multidisciplinary and requires a close collaboration between physicians from various specialties.
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