Metformin to Augment Strength Training Effective Response in Seniors (MASTERS): study protocol for a randomized
Doug E Long1, Bailey D Peck1, Jenny L Martz2
1College of Health Sciences and Center for Muscle Biology, University of Kentucky, Lexington, KY, USA.
Trials
|April 27, 2017
Summary
This study investigates if metformin can enhance muscle gains from resistance training in older adults. It aims to improve muscle mass and strength, boosting functional independence in aging individuals.
Area of Science:
- Gerontology
- Exercise Physiology
- Pharmacology
Background:
- Muscle mass and strength are crucial for quality of life and independence in aging.
- Resistance training is effective against sarcopenia, but older adults show variable and blunted responses.
- Novel strategies are needed to augment resistance training benefits for older individuals.
Purpose of the Study:
- To determine if repurposing metformin can improve the response to resistance exercise training.
- To investigate metformin's effect on the muscle tissue inflammatory environment.
- To enhance muscle mass and strength gains in older adults undergoing resistance training.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving individuals aged 65 and older.
- Participants received metformin (1700 mg/day) or placebo for 2 weeks pre-training, throughout 14 weeks of progressive resistance training, and post-training.
- Muscle biopsies were collected at three time points to analyze cellular and molecular adaptations.
Main Results:
- The study is ongoing; results are pending.
- The trial will compare muscle size, strength, and physical function changes between metformin and placebo groups.
- Individual cellular and molecular adaptations in response to metformin and exercise will be assessed.
Conclusions:
- This is the first metformin repurposing trial for non-diseased individuals targeting the aging 'non-responder' phenotype.
- The trial aims to establish if combined exercise-metformin therapy promotes muscle hypertrophy and strength.
- The ultimate goal is to maintain functional independence in older adults through optimized training responses.
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