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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Active life, active antitumor defense.

Leslie K Ferrarelli1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|April 27, 2017
PubMed
Summary

Regular exercise in mice boosts the nervous system's adrenergic signaling, which improves the cancer-fighting ability of natural killer cells.

Area of Science:

  • Immunology
  • Neuroscience
  • Exercise Physiology

Background:

  • Natural killer (NK) cells are crucial for innate immunity and cancer surveillance.
  • The nervous system's role in modulating immune cell function is increasingly recognized.
  • Adrenergic signaling pathways are known mediators of neuro-immune interactions.

Purpose of the Study:

  • To investigate the impact of an active lifestyle on NK cell function.
  • To determine the role of adrenergic signaling in mediating exercise-induced immune enhancements.
  • To explore the neuro-immune axis in the context of antitumor immunity.

Main Methods:

  • Mice were subjected to voluntary exercise protocols.
  • Adrenergic signaling pathways in the nervous system were analyzed.

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  • NK cell activity and antitumor functions were assessed.
  • Pharmacological interventions targeting adrenergic receptors were employed.

    • Main Results:

    • An active lifestyle significantly enhanced NK cell cytotoxicity and cytokine production.
    • Increased adrenergic signaling was observed in the nervous system of exercising mice.
    • Blocking adrenergic signaling diminished the exercise-induced improvements in NK cell function.
    • Enhanced NK cell infiltration and activity were noted in tumors of active mice.

    Conclusions:

    • Physical activity stimulates neuro-immune pathways, specifically adrenergic signaling.
    • Adrenergic signaling activated by exercise enhances the antitumor capacity of NK cells.
    • Targeting neuro-immune interactions presents a potential strategy for cancer immunotherapy.