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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
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Drug-induced liver injury: Do we know everything?
Tamara Alempijevic1, Simon Zec1, Tomica Milosavljevic1
1Tamara Alempijevic, Simon Zec, Tomica Milosavljevic, University of Belgrade, School of Medicine, 11000 Belgrade, Serbia.
World Journal of Hepatology
|April 27, 2017
Summary
Drug-induced liver injury (DILI) is a growing concern, with over 1000 identified drugs. Despite advances, significant knowledge gaps persist in diagnosing and managing DILI.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Toxicology
Background:
- Drug-induced liver injury (DILI) is a significant clinical concern with increasing interest from various stakeholders.
- Over 1000 drugs are implicated in hepatotoxicity, presenting a wide spectrum of clinical manifestations from asymptomatic elevations to acute liver failure.
- Unregulated herbal and dietary supplements pose new challenges in DILI assessment and management.
Purpose of the Study:
- To review the current state of knowledge regarding drug-induced liver injury (DILI).
- To identify advancements, controversies, and guidelines in the field of DILI.
- To assess the remaining knowledge gaps in understanding and managing DILI.
Main Methods:
- Comprehensive literature review of DILI.
- Analysis of current scientific findings, diagnostic principles, and pathophysiologic mechanisms.
- Examination of clinical management strategies, including causality assessment and treatment options.
Main Results:
- DILI remains a leading cause of acute liver failure and liver transplantation.
- Registries like the U.S. DILI Network and resources like LiverTox have enhanced DILI awareness and research.
- Guidelines for DILI diagnosis and management were established in 2013, alongside progress in identifying risk factors and novel injury mechanisms.
Conclusions:
- Despite significant progress, substantial knowledge gaps persist in the diagnosis, pathophysiology, and management of DILI.
- Continued research is essential to fully understand and address the complexities of drug-induced liver injury.
- The evolving landscape of DILI necessitates ongoing investigation into novel therapeutic strategies and improved diagnostic tools.
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