Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

410
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
410
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

1.3K
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Triglyceride-Glucose Index with Angiographic Thrombus Burden in Patients with ST-Elevation Myocardial Infarction: A Prospective Observational Study.

Journal of clinical medicine·2026
Same author

An Individualized Right-to-Left Tunneling "Bail-Out" for Complex ICD Upgrade in a Pacemaker-Dependent Patient: A Case Report and Literature Review.

Journal of personalized medicine·2026
Same author

Comparative efficacy and safety of catheter ablation energy modalities for atrial fibrillation: A network meta-analysis of randomized trials.

Heart rhythm·2026
Same author

Navigating the Zero Fluoroscopy Frontier: Current Tools, Evidence and Future Directions in Electrophysiology Procedures.

Pacing and clinical electrophysiology : PACE·2026
Same author

Quantifying the Learning Curve in Ultrasound-Guided Vascular Access: Proficiency Metrics of Self-Taught Axillary Vein Puncture for CIED Implantation.

Medical sciences (Basel, Switzerland)·2026
Same author

Association of the Triglyceride-Glucose Index with Major Adverse Cardiovascular Events in Patients with Acute Coronary Syndromes: A Systematic Review and Meta-Analysis.

Medicina (Kaunas, Lithuania)·2026

Related Experiment Video

Updated: Mar 3, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

12.8K

Remote Ischemic Conditioning and Renal Protection.

Georgios Giannopoulos1,2, Dimitrios A Vrachatis3, Vasiliki Panagopoulou1

  • 11 Second Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Journal of Cardiovascular Pharmacology and Therapeutics
|April 27, 2017
PubMed
Summary
This summary is machine-generated.

Remote ischemic conditioning (RIC) shows potential for protecting tissues from damage, but clinical trial results for preventing acute kidney injury (AKI) are mixed. A standardized framework is needed to clarify RIC's true clinical utility.

Keywords:
ischemia–reperfusion injuryischemic conditioningkidney injurypostconditioningpreconditioningrenal failure

More Related Videos

Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.6K
Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
12:27

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

51.5K

Related Experiment Videos

Last Updated: Mar 3, 2026

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

12.8K
Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.6K
Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration
12:27

Renal Ischaemia Reperfusion Injury: A Mouse Model of Injury and Regeneration

Published on: June 7, 2014

51.5K

Area of Science:

  • Cardiovascular and Renal Medicine
  • Translational Medicine
  • Clinical Trial Design

Background:

  • Remote ischemic conditioning (RIC) is an inexpensive intervention to protect tissues from ischemic damage.
  • Acute kidney injury (AKI) is a frequent complication of medical procedures, with RIC proposed as a preventative measure.
  • Existing research on RIC for AKI prevention yields conflicting results.

Purpose of the Study:

  • To critically appraise the current evidence on RIC for preventing AKI.
  • To highlight the inconsistencies in definitions, procedures, outcomes, and goals across RIC studies.
  • To advocate for a standardized clinical trial framework for ischemic conditioning research.

Main Methods:

  • Review of numerous studies and meta-analyses evaluating RIC's effect on kidney function.
  • Analysis of recent large-scale randomized controlled trials (RCTs) in cardiac surgery.
  • Critical appraisal of data quality and methodological shortcomings in published RIC research.

Main Results:

  • Individual studies suggest potential benefits of RIC for kidney function.
  • Three large RCTs (over 1000 patients each) investigating RIC in cardiac surgery yielded negative outcomes.
  • Meta-analyses report mixed results, with recent analyses showing benefit but noting significant data quality issues.

Conclusions:

  • Despite a decade of research, the clinical utility of RIC for AKI prevention remains uncertain.
  • Inconsistencies in study designs and outcome reporting hinder definitive conclusions.
  • A unified clinical trial framework is essential to establish the efficacy and application of ischemic conditioning.